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Abstracts:
Prevalence and Predictors of High-risk Human Papilloma Virus Infection in a Population-based Sample of Women in Rural Uganda
17th April 2009.
Corresponding Author: Stephen Asiimwe, MBChB, MS, Kabwohe Clinical Research Center (KCRC), asiimwes@kcrc.or.ug
ABSTRACT
Background
High-risk genital Human Papilloma Virus (HPV) infection is etiologically linked to cervical cancer; however data on the prevalence and determinants of high-risk HPV infection in Uganda are limited.
Methods
We conducted a population based cross-sectional survey among 18-49 year old women in rural South-west Uganda. The primary outcome was presence or absence of high-risk HPV DNA (for genotypes 16,18,31,33,35,39,45,51,52,56,58,59 or 68) in the genital secretions as determined by HPV DNA Hybrid Capture 2 assay (Digene Corp, Beltsville, MD).
Results
The prevalence of high-risk HPV was 17.2 % (54/314; 95% confidence interval (CI):13-21). Younger women had a higher proportion of high-risk HPV infection; with a 9% increase in the odds of high-risk HPV infection per year decrease in age, (OR= 0.91; 95% CI: 0.86-0.96). The odds of high risk HPV infection among women with history of a prior HIV serological test result (n=151) was 12.2, 95% CI (2.8-52.8) among those HIV positive compared to those HIV negative.
Conclusion
In this population of rural Ugandan women, the prevalence of high-risk cervical HPV infection is high. Information on predictors of high risk HPV infection and intention to receive a vaccine can guide future immunization initiatives for young sexually active women.
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